منابع مشابه
Structure-activity relationships of taxoids: a molecular descriptors family approach
Introduction: Taxoids, groups of diterpenoid cyclodecanes isolated from the genus Taxus, are known and used as anticancer agents. Starting from the successful results obtained by an original molecular descriptors family on structure-activity relationships (Jäntschi and Bolboacă, 2007), the aim of the research was to investigate and to assess the estimation and prediction abilities of this appro...
متن کاملIn vivo antitumor activity of novel water-soluble taxoids.
The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-alpha-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent...
متن کاملRole of taxoids in head and neck cancer.
Docetaxel and paclitaxel represent a new class of cytotoxic agents having both a specific chemical structure and mechanism of action. They act to promote tubulin polymerization and the formation of stable microtubules. The microtubules produced in the presence of taxoids are resistant to disassembly by physiologic stimuli, and cells exposed to these agents exhibit an accumulation of disorganize...
متن کاملPREPARATION AND APPLICATIONS OF FLUORESCENT POLYGLUTARALDEHYDE IMMUNOMICROSPHERES
Aqueous glutaraldehyde has been polymerized under alkaline conditions in the presence of a surfactant to yield microspheres of varied diameters. Microbeads of a nominal 300 nm diameter, made fluorescent via fluoresceinisothiocyanate, were used as a carrier of rabbit anti-human red blood cell antibodies. Specific labeling of the human red blood cells as well as diagnostic use of these fluor...
متن کاملSimultaneous identification and determination of major taxoids from extracts of Taxus chinensis cell cultures.
Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/ MS) and high-performance liquid chromatography (HPLC) methods have been used to identify and quantify the major taxoids from extracts of Taxus chinensis cell cultures. Chromatography was carried out on a reverse phase C18 column with isocratic-mode elution. By analytically comparing LC/ESI-MS/MS of the extracts w...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 1996
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(96)90168-4